目的 研究宽苞糙苏根的化学成分。方法 用硅胶柱色谱、凝胶柱色谱、以及制备高效液相色谱等多种色谱分离手段进行分离纯化,用有机波谱手段鉴定分离得到的化合物结构。结果 从宽苞糙苏根的体积分数95%乙醇提取物中分离得到17个化合物,分别鉴定为lamalbid(1),螃蟹甲苷Ⅰ(2),螃蟹甲苷Ⅱ(3),山栀苷甲酯(4),6-乙酰山栀苷甲酯(5),8-乙酰山栀苷甲酯(6),sesamoside(7),5,9-epi-7,8-didehydropenstemoside(8),毛蕊花糖苷(9),异毛蕊花糖苷(10),连翘酯苷B (11),alyssonoside (12),松果菊苷(13),(17S)-2α,3α,18β,23,24-pentahydroxy-19(18→17)-abeo-28-norolean-12-en-21-one (14),(17S)-19(18→17)-abeo-12-en-28-norolean-2α,3α,18β,19,23,24-hexaol (15),木栓酮(16)和大豆苷 (17)。结论 所有化合物均为首次从宽苞糙苏中分离得到的化合物,其中化合物1,8,16~17为首次从糙苏属中分离得到的化合物。
Abstract
OBJECTIVE To study the chemical constituents from the rhizome of Phlomis umbrosa. METHODS Chemical constituents were isolated by repeated column chromatographies(Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. RESULTS Seventeen compounds were isolated from the 95% ethanol aqueous extract of P. umbrosa and the structures were identified as lamalbid (1), phloyoside Ⅰ(2), phloyoside Ⅱ(3), 6-O-acetylshanzhiside methyl ester(4), shanzhiside methyl ester (5), 8-acetylshanzhiside methyl ester(6), sesamoside(7), 5,9-epi-7,8-didehydropenstemoside(8), verbascoside(9), isoverbascoside(10), forsythoside B(11), alyssonoside(12), echinacoside(13), (17S)-2α,3α,18β,23,24-pentahydroxy-19(18→17)-abeo-28-norolean-12-en-21-one(14),(17S)-19(18→17)-abeo-12-en-28-norolean-2α,3α,18β,19,23,24-hexaol (15), friedelin(16), and daidzein(17). CONCLUSION All compounds are isolated from this plant for the first time, compounds 1, 8, 16-17 are isolated from genus Phlomis for the first time.
关键词
宽苞糙苏 /
lamalbid /
螃蟹甲苷 /
环烯醚萜苷 /
苯乙醇苷 /
降三萜
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Key words
Phlomis umbrosa /
lamalbid /
phloyoside /
iridoid glycoside /
phenylethanoid glycoside /
nortriterpene
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脚注
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基金
国家自然科学基金-河南联合基金项目资助(U1404831)
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